Antidepressant intoxication
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== Antidepressants ==
- Frequent intoxication, these are substances that inhibit the reuptake of catecholamines and serotonin in the synapse, significant anticholinergic effects,
- representatives of TCAs (tricyclic antidepressants) – imipramine' (Melipramine®), amitryptiline', dosulepin' (Prothiaden®),
- have cardiotoxic manifestations - already at 10 times the therapeutic dose!
Clinical picture[edit | edit source]
- Poisoning TCA will cause an anticholinergic syndrome - dryness of the mucous membranes, mydriasis, tachycardia, slowing of the GIT, retention of urinee,
- impaired consciousness, convulsions,
- EKG – prolongation of the nitroventricular conduction (QRS widening), dysrhythmia (danger of ventricular fibrillation).
Therapy[edit | edit source]
- The antidote is not
- basis of treatment – high doses of activated charcoal, care of vital functions, symptomatic therapy.
Links[edit | edit source]
Related Articles[edit | edit source]
Source[edit | edit source]
- BENEŠ, George. Study Materials [online]. [cit. 2010-02-24]. <http://jirben.wz.cz>.
References[edit | edit source]
- PELCLOVÁ, Daniela. Occupational diseases and intoxication. 2. edition. Prague : Karolinum, 2006. 207 pp. ISBN 80-246-1183-X.
